Multiple Myeloma Treatment: Whats New?

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Treatments formultiple myelomahave grown a great deal in the past few years. Newerdrugshelp people with thisblood cancerlive longer and enjoy a better quality of life.

Several drugs have been approved to treat multiple myeloma since 2015. Some can help when the disease comes back after treatment (called a relapse) or when the cancer doesnt respond to the first line of treatment (called refractory multiple myeloma).

Some of these newer drugs are:

Belantamab mafodotin-blmf(Blenrep)is the first in a class of drugs called antibody drug conjugates (ADC). These meds combine a monoclonal antibody drug andchemotherapyin one drug. Belantamab mafodotin-blmf can treat people whove been already treated with at least four prior therapies, including:

  • An anti-CD38 monoclonal antibody like daratumumab (Darzalex). This targets a protein on the surface of myeloma cells called CD38.
  • A proteasome inhibitor like bortezomib (Velcade). This drug blocks substances called proteasomes, which help cancer cells recycle proteins they need to grow.
  • An immunomodulatory agent. These meds use your bodys defenses (your immune system) to attack myeloma cells. Examples of these drugs are lenalidomide (Revlimid), pomalidomide (Pomalyst), and thalidomide (Thalomid).

Belantamab mafodotin-blmf targets the protein BCMA (B-cell maturation antigen), which is the protein that protects the cancer cell.

Ciltacabtagene autoleucel (Carvykti) is a type of CAR-T therapy. That means it uses cells from your immune system to fight cancer. Ciltacabtagene autoleucel can treat adults with relapsed or refractory multiple myeloma whove had four or more different types of treatment, including:

  • A proteasome inhibitor
  • An immunomodulatory agent
  • And an anti-CD38 monoclonal antibody

Each dose of the treatment is tailored for you using your own T cells — a type of disease-fighting white blood cell to help attack the myeloma. Your treatment team collects and genetically changes your T cells, then puts them back into your body.

Daratumumab(Darzalex)is a monoclonal antibody. It revs up your immune systemto help you fight the cancer.

You can take this drug either alone or combined with bortezomib (Velcade), melphalan (Alkeran), and prednisone or with dexamethasone and lenalidomide (Revlimid). It depends on whether youre newly diagnosed, prior treatments havent helped you, or the disease has relapsed.

Daratumumab targets a protein on the surface of myeloma cells called CD38. It seeks out the protein and then kills the cancer cells its attached to.

Elotuzumab(Empliciti)is another monoclonal antibody. It searches for a molecule on cancer cells called SLAMF7.

Its combined with other myeloma drugs: either withlenalidomide(Revlimid) and dexamethasone, or with dexamethasone and a newer drug calledpomalidomide (Pomalyst). It works for people with more aggressive forms of myeloma.

Idecabtagene vicleucel (Abecma) was the first CAR-T therapy to treat adults with multiple myeloma. Its for people who havent responded to — or whose disease has come back after — at least four different types of treatment.

Isatuximab(Sarclissa)is a monoclonal antibody that works similar to daratumumab. Its used together with pomalidomide and dexamethasone for people whove tried at least two other treatments. It also targets CD38 and slows the growth of cancer. It can also be used with carfilzomib (Kyprolis) and dexamethasone, to treat people who have tried one to three other treatments.

Ixazomib(Ninlaro)is the first and only oral proteasome inhibitor taken by mouth that the FDA has approved for multiple myeloma. Proteasomes are enzyme complexes that help cancer cells recycle proteins they need to grow. Ixazomib blocks proteasomes to kill myeloma cells.

It’s combined with lenalidomide (Revlimid) and dexamethasone. It’s used in people whove tried at least one other myeloma treatment.

Selinexor(Xpovio)is a newer type of multiple myeloma drug called a selective inhibitor of nuclear export (SINE). It works by blocking XPO1, a protein that allows cancer cells to thrive.

The FDA approved selinexor for treatment of relapsed or refractory disease. Its combined with dexamethasone and is used to treat people who’ve tried at least four previous treatments. It can also be used with dexamethasone or bortezomib in people who have tried at least one other treatment.

Whats on the Horizon?

Some potential breakthroughs in multiple myeloma therapy are still in the test phase, but they seem very promising, says Hans C. Lee, MD, an assistant professor at the University of Texas MD Anderson Cancer Center in Houston.

For example, T-cell engagersare antibodies that fight cancer cells in two separate ways: They look for BCMA and T cells, which are part of your own immune system, Lee says.

One arm of the antibody searches for BCMA on the myeloma cells surface. The other arm looks for a protein called CD3 on T cells. Lee says its basically the kiss of death for the cancer cells. The T cell is activated (turned on), it comes into contact with the myeloma cell, then kills it, he says. These drugs are also called bispecific T-cell engager antibodies, or BiTEs.

Another positive step for multiple myeloma treatment is the advance in genomic medicine, says Lee. Doctors are able to do abiopsy, or tissue sample, and see gene-related information about your cancer more quickly and cheaply than in the past. Lee says that hopefully, doctors will soon be able to use this data in real time, possibly to help find the ideal way to sequence your treatments or even to individualize treatment.



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